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What if my low energy isn’t depression?

Not all fatigue is depression. Here’s how we explore other root causes — and build a plan that actually makes sense.

Updated this week

If you’re dragging through the day, feel like your brain’s running on fumes, or constantly need caffeine to function — but you’re not sad, withdrawn, or hopeless — it may not be depression.

Low energy can be caused by many things. And at Fishtown Medicine, we take the time to figure out which ones matter for you.


⚠️ When low energy is not depression:

You might feel:

  • Mentally foggy or slow

  • Physically drained, no matter how much you sleep

  • Unmotivated but not emotionally numb

  • Easily overwhelmed by simple tasks

  • Like your body just can’t “get into gear”

But you’re still laughing sometimes. You’re still connected to people. You still want to feel better — you just don’t have the fuel.


🧪 What we check when fatigue is the main issue:

  • Thyroid health (TSH, Free T4, Reverse T3, antibodies)

  • Iron and ferritin (especially in menstruating people)

  • B12 and methylation markers

  • Sleep quality and apnea screening

  • Adrenal rhythm / cortisol imbalance

  • Sex hormones (low testosterone, estrogen/progesterone imbalance)

  • Mitochondrial function and inflammation markers

  • Insulin resistance or blood sugar swings

  • Post-viral fatigue or long COVID patterns


🧠 It’s not all about labs either.

We also explore:

  • Overtraining or under-recovery

  • Trauma-related exhaustion or burnout masking as laziness

  • Sleep timing and circadian mismatch

  • Poor fit between your routine and your energy profile

  • Medications or supplements that may be draining you


🔄 What we do instead of guesswork:

  • Track your symptoms over time (energy logs, wearable data)

  • Pair labs with how you actually feel day-to-day

  • Adjust movement, nutrition, and rhythms in a way that respects your energy — rather than overriding it

  • Deprescribe when appropriate

  • Build a care plan that supports your mitochondria, nervous system, and hormones — not just your mood


💡 The bottom line:

Just because you're tired doesn't mean you're depressed.
And just because your labs are “normal” doesn’t mean you’re fine.

Low energy deserves real investigation — and a real plan.

If this sounds familiar, we can walk through what might be driving your fatigue and what we can do about it.

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